AMD EPYC 7543

Model (Tray P/N): 100-000000345
Status: Unlocked (No Vendor Lock)
Socket: SP3

The AMD EPYC 7543 is a 3rd Generation “Milan” (Zen 3) server processor engineered for high-performance data center workloads. Featuring 32 cores, 64 threads, and a massive 256MB L3 cache, it delivers exceptional multi-threaded performance, PCIe 4.0 connectivity, and enterprise-grade scalability for virtualization, databases, HPC, and cloud deployments.

Core Specifications

• Architecture: Zen 3 (Milan)

• Cores / Threads: 32 Cores / 64 Threads

• Base Clock: 2.80 GHz

• Max Boost Clock: Up to 3.70 GHz

• L3 Cache: 256 MB

• Socket Type: SP3

• TDP: 225W (Configurable up to 240W cTDP)

• Manufacturing Process: TSMC 7nm FinFET

• Transistor Count: 33.2 billion

Memory & I/O Capabilities

• Memory Type: DDR4 ECC RDIMM / LRDIMM

• Memory Speed: Up to 3200 MT/s

• Memory Channels: 8-channel architecture

• Max Memory Capacity: Up to 4TB (platform dependent)

• Memory Bandwidth: 204.8 GB/s

• PCIe Version: PCIe 4.0

• PCIe Lanes: 128 lanes

For optimal performance, populate all 8 memory channels with identical modules.

Scalability

• Platform Support: 1P (Single Socket) or 2P (Dual Socket)

• Designed for enterprise virtualization clusters, high-core database servers, and GPU-accelerated workloads.

Motherboard Compatibility (SP3 – Milan Required)

Requires a Socket SP3 motherboard with BIOS support for EPYC 7003 (Milan).

Examples:

• ASRock Rack ROMED8-2T

• Gigabyte MZ32-AR0

⚠ Systems originally shipped with EPYC 7002 (Rome) require BIOS updates for Milan support.

OEM Server Compatibility

Officially supported in major 2021+ platforms designed for EPYC 7003:

Dell PowerEdge

• Dell PowerEdge R6525

• Dell PowerEdge R7525

• Dell PowerEdge R7515

• Dell PowerEdge C6525

HPE ProLiant

• HPE ProLiant DL325 Gen10 Plus v2

• HPE ProLiant DL385 Gen10 Plus v2

• HPE ProLiant DL345 Gen10 Plus

• HPE ProLiant DL365 Gen10 Plus

Lenovo ThinkSystem

• Lenovo ThinkSystem SR645

• Lenovo ThinkSystem SR665

• Lenovo ThinkSystem SR635

• Lenovo ThinkSystem SR655

Supermicro A+ Platforms

• Supermicro AS-1124US-TNRP

• Supermicro AS-2124BT-HTR

Cooling Requirements (225W TDP)

Due to its high TDP, enterprise-grade SP3 cooling is required.

Examples:

• Dynatron A26 (Up to 280W)

• Dynatron A38 (Up to 280W)

• Noctua NH-U14S TR4-SP3

Standard consumer coolers are not compatible with the SP3 socket.

Power Recommendations

• Single-Socket Build: 850W–1000W PSU (80+ Gold recommended)

• Dual-Socket Build: 800W+ per PSU (server redundant configuration typical)

Ideal for systems with high PCIe utilization (NVMe arrays, GPUs).

Important Purchasing Note – Vendor Locking

Part number 100-000000345 is commonly found on the secondary market.

• Locked Units: Some are vendor-locked to specific OEM systems (e.g., Dell).

• Unlocked Units: Fully compatible with standard SP3 Milan motherboards.

Always verify listing states “Unlocked” or “No Vendor Lock” if installing outside the original OEM platform.

Other Related Part Numbers / OEM Kit Numbers

This CPU may also be referenced under the following OEM or kit part numbers and may be sold as part of complete processor kits:

• 100-000000345

• 338-BZRP

• XN6RX / 0XN6RX

• G7C32

• P39059-001

• P38687-B21

• P40590-B21

• P38717-B21

• P40601-B21

• P38728-B21

• P38728-L21

• 5B27A24190

• 4XG7A63589

• 4XG7A63608

• UCS-CPU-A7543

• PSE-MLN7543-0345

These part numbers may represent:

• OEM-branded versions (Dell, HPE, Lenovo, Cisco)

• Retail option kits

• Spare part replacements

• System-integrated CPU assemblies

The AMD EPYC 7543 is functionally equivalent across these references when specifications match (32C / 2.8GHz / 256MB / 225W / SP3 Milan).

Summary

The AMD EPYC 7543 (100-000000345) is a 32-core, 64-thread Milan processor built for enterprise and HPC environments. With 256MB L3 cache, 128 PCIe 4.0 lanes, and 8-channel DDR4-3200 support, it provides exceptional scalability and performance in both 1P and 2P server configurations.